PHOSPHOLIPIDS BOUND TO ACIDIC NUCLEAR PROTEINS IN HUMAN B-LYMPHOCYTES AND T-LYMPHOCYTES

被引：30

作者：

MANZOLI, FA

COCCO, L

FACCHINI, A

CASALI, AM

MARALDI, NM

GROSSI, CE

机构：

[1] UNIV CHIETI, IST ISTOL & EMBRIOL GEN, CHIETI, ITALY

[2] UNIV GENOVA, GENOVA, ITALY

[3] UNIV BOLOGNA, IST ISTOL & EMBRIOL GEN, I-40126 BOLOGNA, ITALY

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1976年 / 12卷 / 02期

关键词：

D O I：

10.1007/BF01731551

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromatin fractions (DNA, histones and non-histone chromosomal proteins [NHCP]) were isolated from human peripheral B [bone marrow-derived] and T [thymus-derived] lymphocytes using different methods and analyzed to identify their lipid content. While DNA and histone fractions do not reveal the presence of lipids, 2% phospholipid is present in the NHCP fraction. The phospholipids associated with NHCP present a constant relative ratio among sphingomyelin, phosphatidyl-choline and phosphatidyl-ethanolamine in B and T lymphocytes, regardless of the extraction procedures employed. These findings are related to the possible derepressive role of phospholipids on DNA-dependent RNA synthesis.

引用

页码：67 / 71

页数：5

共 37 条

[1] ATTACHMENT OF NUCLEAR-PORE COMPLEX [J].