STIMULATION OF GUANYLATE CYCLASE ACTIVITY BY SEVERAL FATTY-ACIDS

被引：40

作者：

ASAKAWA, T ^{[1
]}

SCHEINBAUM, I ^{[1
]}

HO, RJ ^{[1
]}

机构：

[1] UNIV MIAMI, SCH MED, DEPT BIOCHEM, EARL W SUTHERLAND RES LABS, MIAMI, FL 33152 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 73卷 / 01期

关键词：

D O I：

10.1016/0006-291X(76)90508-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Guanylate cyclase of plasma membrane of isolated rat fat cells was activated 7- to 11-fold by oleic acid, linoleic acid, linolenic acid or arachidonic acid. The activation of the enzyme by linoleic acid or oleic acid was influenced by the concentration of enzyme protein and that of the fatty acid. At 158 .mu.g/ml of enzyme protein, 0.6 mM linoleic acid produced maximal activation of 12-fold which was partially reversed by washing. Particulate guanylate cyclase of cerebral cortex and liver was also activated by linoleic acid.

引用

页码：141 / 148

页数：8

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