COMPARISON OF IMMUNOSUPPRESSIVE EFFICACY OF 6-MERCAPTOPURINE, AZATHIOPRINE, CYCLOPHOSPHAMIDE AND 036.5122 (ASTA) ON PRIMARY AND SECONDARY IMMUNE-RESPONSE OF MICE TO SHEEP ERYTHROCYTES

被引:6
作者
BOTZENHARDT, U [1 ]
LEMMEL, EM [1 ]
机构
[1] UNIV MAINZ, INST MED MIKROBIOL, D-6500 MAINZ, FED REP GER
来源
AGENTS AND ACTIONS | 1976年 / 6卷 / 05期
关键词
D O I
10.1007/BF01971576
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two alkylating (cyclophosphamide and 036.5122 Asta [3-(2-chloroethyl)-2-(2-mesyloxyethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide]) and 2 antiproliferative agents (6-mercaptopurine and azathioprine) are compared for their immunosuppressive potency on the primary and secondary humoral immune response of mice. If equitoxic dosages of the respective drugs are compared, the alkylating agents had much higher immunosuppressive potency than the antiproliferative agents. In nontoxic dosages alkylating agents were able to completely inhibit a primary or secondary immune response, while a similar effect with antiproliferative drugs could not be obtained even within toxic dose ranges. Induction of immunological tolerance was possible only by use of alkylating agents. The significance of these comparative studies is discussed in view of the frequent use of tested drugs in clinical immunosuppression.
引用
收藏
页码:596 / 601
页数:6
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