SUSTAINED-RELEASE MATRIX OF MEBEVERINE HYDROCHLORIDE USING POLYACRYLATE RESIN EUDRAGIT RETARD KINETIC OF DRUG RELEASE AND EVALUATION OF A KINETIC-MODEL

In this study Eudragit RS PM and RL PM were evaluated as carriers for the preparation of prolonged release solid dispersions of mebeverine hydrochloride by solvent and melting methods. The prepared tablets were examined for dissolution at pH 1.2 and 7.4, Eudragit RS PM and RL PM were found satisfactory as potential slow release carriers. The solid dispersion prepared by the solvent method showed a slow release pattern. Drug release appeared to fit both, first order and Higuchi matrix model kinetics. However, on application of the differential rate treatments, the evidence supported the Higuchi matrix model. Effect of temperatures on dissolution rate was studied for thermodynamic consideration. The drug release was pH - independent until pH 7.4. As the pH increased, the release was significantly reduced due to solubility problem.