GENOTOXICITY OF PYRENE OXIDE AND 1-NITROPYRENE OXIDES IN HEPATOCYTE PRIMARY CULTURE DNA-REPAIR TEST

被引：3

作者：

MORI, H ^{[1
]}

SUGIE, S ^{[1
]}

OKUMURA, A ^{[1
]}

HARA, A ^{[1
]}

KINOUCHI, T ^{[1
]}

KATAOKA, K ^{[1
]}

OHNISHI, Y ^{[1
]}

机构：

[1] UNIV TOKUSHIMA,SCH MED,DEPT BACTERIOL,TOKUSHIMA 770,JAPAN

来源：

MUTATION RESEARCH | 1991年 / 262卷 / 04期

关键词：

GENOTOXICITY; HEPATOCYTE DNA REPAIR; PYRENE OXIDE; NITROPYRENE OXIDES;

D O I：

10.1016/0165-7992(91)90089-M

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genotoxicity of a pyrene oxide, 1-nitropyrene (NP) oxides and other related compounds was examined in the hepatocyte primary culture (HPC)/DNA repair test. Pyrene 4,5-oxide and both 1-NP-4,5-oxide and 1-NP-9,10-oxide elicited clearly positive responses of DNA repair. In this assay, 1-NP itself was weakly positive. However, other related chemicals such as pyrene, 1-nitro-3-hydroxypyrene, 1-nitro-6-hydroxypyrene, and 1-nitro-8-hydroxypyrene did not generate positive responses.

引用

页码：233 / 238

页数：6

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