DIFFERENTIAL MEMBRANE-PROPERTIES AND DOPAMINE EFFECTS IN THE SHELL AND CORE OF THE RAT NUCLEUS-ACCUMBENS STUDIED INVITRO

被引：95

作者：

PENNARTZ, CMA

DOLLEMANVANDERWEEL, MJ

DASILVA, FHL

机构：

[1] Neurophysiology Division, Department of Experimental Zoology, University of Amsterdam, Amsterdam

来源：

NEUROSCIENCE LETTERS | 1992年 / 136卷 / 01期

关键词：

DOPAMINE; MEDIUM SPINY NEURON; MEMBRANE PROPERTY; NUCLEUS ACCUMBENS; POSTSYNAPTIC POTENTIAL; SLICE PREPARATION; VENTRAL STRIATUM;

D O I：

10.1016/0304-3940(92)90660-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Electrophysiological differences between the shell and core of the rat nucleus accumbens were investigated by intracellular recordings from an in vitro slice preparation. The average input resistance of neurons recorded in the shell was larger than in the core. Neurons in the core were characterized by a more negative resting membrane potential than neurons in the shell. Furthermore, bath-applied dopamine attenuated synaptic responses recorded in the shell, but not in the core. Thus, the two main subregions of the nucleus accumbens differ both in basal membrane properties and in dopaminergic modulation of synaptic transmission.

引用

页码：109 / 112

页数：4

共 21 条

[1] NEW PERSPECTIVES IN BASAL FOREBRAIN ORGANIZATION OF SPECIAL RELEVANCE FOR NEUROPSYCHIATRIC DISORDERS - THE STRIATOPALLIDAL, AMYGDALOID, AND CORTICOPETAL COMPONENTS OF SUBSTANTIA INNOMINATA [J].