ENHANCEMENT OF MESSENGER-RNA SYNTHESIS FROM MAREKS-DISEASE VIRUS GENOME IN THE LYMPHOBLASTOID CELL-LINE, MDCC-MSB1, BY 5-AZACYTIDINE

被引：9

作者：

HAYASHI, M

FURUICHI, T

REN, S

ISOGAI, E

NONOYAMA, M

NAMIOKA, S

机构：

[1] HIGASHI NIPPON GAKUEN UNIV,SCH DENT,DEPT PREVENT DENT,ISHIKARI,HOKKAIDO 06102,JAPAN

[2] TAMPA BAY RES INST,ST PETERSBURG,FL 33716

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1994年 / 56卷 / 02期

关键词：

LYMPHOBLASTOID CELL; MDV DNA; METHYLATION; MESSENGER-RNA SYNTHESIS; 5-AZC;

D O I：

10.1292/jvms.56.287

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Marek's disease virus (MDV) DNA in latently infected lymphoblastoid cell lines is considerably methylated. A treatment of the MDV-derived lymphoblastoid cell line, MDCC-MSB1 (MSB1), with 5-azacytidine (5-AzC) resulted in a hypomethylation of MDV DNA and an increase in mRNA from certain portions of the MDV DNA. These results suggest methylation of MDV DNA as being one of the factors associated with a repression of transcription of MDV DNA in the lymphoblastoid cell line, MSB1.

引用

页码：287 / 291

页数：5

共 32 条

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