HIGH SERUM LEVEL OF THE SOLUBLE FORM OF CD30 MOLECULE IN THE EARLY PHASE OF HIV-1 INFECTION AS AN INDEPENDENT PREDICTOR OF PROGRESSION TO AIDS

被引:139
作者
PIZZOLO, G
VINANTE, F
MOROSATO, L
NADALI, G
CHILOSI, M
GANDINI, G
SINICCO, A
RAITERI, R
SEMENZATO, G
STEIN, H
PERONA, G
机构
[1] UNIV VERONA,SCH MED,POLICLIN BORGO ROMA,DEPT PATHOL,VERONA,ITALY
[2] UNIV VERONA,SCH MED,POLICLIN BORGO ROMA,DEPT TRANSFUS,VERONA,ITALY
[3] UNIV VERONA,SCH MED,POLICLIN BORGO ROMA,IMMUNOHAEMATOL SERV,VERONA,ITALY
[4] UNIV TURIN,SCH MED,INST INFECT DIS,TURIN,ITALY
[5] UNIV PADUA,SCH MED,MED CLIN 1,PADUA,ITALY
[6] FREE UNIV BERLIN,KLINIKUM STEGLITZ,INST PATHOL,BERLIN,GERMANY
关键词
CD30; HIV-1; INFECTION; PROGNOSTIC MARKERS;
D O I
10.1097/00002030-199406000-00003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To determine the serum levels of the soluble form of the CD30 (sCD30) activation molecule in the early phase of HIV-1 infection, and to investigate the possible correlation with evolution to AIDS. Methods: sCD30 values were determined by an enzyme-linked immunosorbent assay (ELISA) on serum samples collected at the time of the first evidence of HIV-1 infection in 110 individuals with a median follow-up of 56 months (range, 12-88 months), at the A1 (74 cases) or A2 (36 cases) stages of the 1993 revised Centers for Disease Control and Prevention classification. The data were evaluated using established clinical and immunological parameters, including circulating CD4+ T-cell count. The controls were 110 blood donors and 51 HIV-1-negative subjects belonging to groups at risk for HIV-1 infection. Results: Elevated sCD30 levels (> 20 U/ml) were found in 83.6% of HIV-1-infected cases and in 47% of at-risk seronegatives. Data analysis revealed that HIV-1-infected patients with higher sCD30 levels (> 35 U/ml) experienced faster disease progression (P=0.0002). Th is was also the case in patients at the earliest stage (A1) of HIV infection (P=0.0027). In these latter cases the predictive value of sCD30 was independent of the initial absolute number of circulating CD4+ lymphocytes. Conclusions: Serum levels of sCD30 are increased in the large majority of patients in the early phase of HIV-1 infection and represent an indicator of progression to AIDS independent of other prognostic parameters.
引用
收藏
页码:741 / 745
页数:5
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