ENDOTOXIN ANTAGONISTS - POSSIBLE CANDIDATES FOR THE TREATMENT OF GRAM-NEGATIVE SEPSIS

被引：16

作者：

HOLST, O

机构：

[1] Forschungsinstitut Borstel, Institut für Experimentelle Biologie und Medizin, Borstel, D-23845

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1995年 / 34卷 / 18期

关键词：

DRUGS; ENDOTOXINS; LIPOPOLYSACCHARIDES; MEDICINAL CHEMISTRY;

D O I：

10.1002/anie.199520001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The acylation and phosphorylation pattern determines the effectiveness of disaccharide antagonists of lipid A (lipid A from Escherichia coli is shown on the right), the toxic principle of sepsis‐inducing endotoxins from Gram‐negative bacteria. These antgonists, which have not shown toxic activity for humans, have now been synthesized. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：2000 / 2002

页数：3

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