SYNTHESIS OF THE NAPHTHALENIC BIOISOSTERE OF THE ANTIMIGRAINE DRUG SUMATRIPTAN

被引：6

作者：

ABDELLAOUI, H

DEPREUX, P

LESIEUR, D

PFEIFFER, B

BONTEMPELLI, P

机构：

[1] FAC SCI PHARMACEUT & BIOL LILLE,CHIM THERAPEUT LAB,F-59006 LILLE,FRANCE

[2] SOC ADIR,F-92415 COURBEVOIE,FRANCE

来源：

SYNTHETIC COMMUNICATIONS | 1995年 / 25卷 / 09期

关键词：

D O I：

10.1080/00397919508013831

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1-(2-dimethylaminoethyl)-7-N-(methylaminosulfonylmethyl)naphthalene (1), a naphthalenic bioisostere of the antimigraine drug, sumatriptan is described through a 8 steps reaction strategy from 2-methylnaphthalene.

引用

页码：1303 / 1311

页数：9

共 19 条

[1] REACTION OF BENZENESELENENYL HALIDES WITH 3-KETO STEROIDS - A NOVEL METHOD FOR ALPHA-BROMINATION [J].

ABULHAJJ, YJ .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (17) :3380-3382

[2]

ADAMS R, 1932, ORG SYNTH, V1, P575

[3]

AMUPITAN JO, 1983, SYNTHESIS-STUTTGART, P730

[4] 5-HT(1)-LIKE RECEPTORS - 6 DOWN AND STILL COUNTING [J].

BEER, MS ;

MIDDLEMISS, DN ;

MCALLISTER, G .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (06) :228-231

[5] THE 5-HT4 RECEPTOR - A PLACE IN THE SUN [J].

BOCKAERT, J ;

FOZARD, JR ;

DUMUIS, A ;

CLARKE, DE .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (04) :141-145

[6] EINE METHODE ZUR KATALYSIERTEN HERSTELLUNG VON CARBONSAURE UND SULFOSAURE-CHLORIDEN MIT THIONYLCHLORID [J].

BOSSHARD, HH ;

MORY, R ;

SCHMID, M ;

ZOLLINGER, H .

HELVETICA CHIMICA ACTA, 1959, 42 (05) :1653-1658

[7]

BUNTON CA, 1952, J CHEM SOC, P4541

[8] CHARACTERIZATION OF 5-HT RECEPTORS MEDIATING CONTRACTION OF CANINE AND PRIMATE BASILAR ARTERY BY USE OF GR43175, A SELECTIVE 5-HT1-LIKE RECEPTOR AGONIST [J].

CONNOR, HE ;

FENIUK, W ;

HUMPHREY, PPA .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 96 (02) :379-387

[9]

DEPREUX P, 1993, Patent No. 4001116

[10]

DOENICKE A, 1988, LANCET, V1, P1309

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