THE FUMARATE REDUCTASE SYSTEM AS A SITE OF ANTHELMINTIC ATTACK IN ASCARIS-SUUM

被引：11

作者：

BARROWMAN, MM ^{[1
]}

MARRINER, SE ^{[1
]}

BOGAN, JA ^{[1
]}

机构：

[1] UNIV GLASGOW, SCH VET, DEPT VET PHARMACOL, GLASGOW G61 1QH, SCOTLAND

来源：

BIOSCIENCE REPORTS | 1984年 / 4卷 / 10期

关键词：

D O I：

10.1007/BF01138170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various benzimidazole compounds are highly effective as inhibitors (up to 50% reduction of activity) in vitro of the helminth-specific enzyme, fumarate reductase, of A. suum. Anthelmintically active and inactive benzimidazoles were similarly effective as inhibitors of enzyme activity. Albendazole-induced inhibition of fumarate reductase was not observed when the enzyme was preincubated with NADH.

引用

页码：879 / 883

页数：5

共 8 条

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BARROWMAN, MM
MARRINER, SE
BOGAN, JA
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