THE CARDIAC EFFECTS OF PARATHYROID-HORMONE IN THE TIGER FROG, RANA-TIGRINA

被引：5

作者：

CHIU, KW ^{[1
]}

LEE, YC ^{[1
]}

PANG, PKT ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT PHYSIOL,EDMONTON T6G 2E1,ALBERTA,CANADA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1990年 / 95卷 / 02期

关键词：

D O I：

10.1016/0742-8413(90)90103-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. The cardiac effects of the N-terminal (1-34) peptide fragment of bovine parathyroid hormone [bPTH-(1-34)] on isolated atria were examined in the frog, Rana tigrina. 2. 2. bPTH-(1-34) produced dose-related inotropic response but no chronotropic response. This inotropic response varied at different times of the year. 3. 3. The inotropic effect of bPTH-(1-34) was attenuated in the presence of verapamil and imidazole. 4. 4. The mechanism of action of bPTH-(1-34) is probably a stimulation of calcium influx directly or indirectly via cAMP production. © 1990.

引用

页码：197 / 199

页数：3

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