MEISENHEIMER REARRANGEMENT OF 2-ETHENYL-1,4,5,10B-TETRAHYDRO-2H-AZETOPYRIDO[3,4-B]INDOLE N-OXIDES - NEW ROUTE TO THE 12(S)CARBA-EUDISTOMIN SKELETON

被引：14

作者：

KURIHARA, T

DOI, M

HAMAURA, K

OHISHI, H

HARUSAWA, S

YONEDA, R

机构：

[1] Osaka University of Pharmaceutical Sciences, Osaka 580, 2-10-65, Kawai, Matsubara

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 03期

关键词：

3,4-DIHYDRO-BETA-CARBOLINE; TETRAHYDROAZETOPYRIDOINDOLE; TETRAHYDROPYRIDOOXAZEPINE; TETRAHYDROPYRIDOISOXAZOLE; MEISENHEIMER REARRANGEMENT; M-CHLOROPERBENZOIC ACID; CARBAEUDISTOMIN; X-RAY ANALYSIS;

D O I：

10.1248/cpb.39.811

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oxidation of 1,2-cis- and 1,2-trans-2-ethenyl-1,4,5, 10b-tetrahydro-2H-azetopyrido[3,4-b]indoles 4 and 5 with m-chloroperbenzoic acid (mCPBA) gave tetrahydropyridooxazepine 7, which has a 12(S) carba-eudistomin skeleton, and tetrahydropyridoisoxazole 8 by Meisenheimer rearrangement.

引用

页码：811 / 813

页数：3

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