26,27-HEXAFLUORO-1,25-DIHYDROXYVITAMIN-D3 (F6-1,25(OH)2D3) PREVENTS OSTEOPOROSIS INDUCED BY IMMOBILIZATION COMBINED WITH OVARIECTOMY IN THE RAT

被引:14
作者
OKUMURA, H
YAMAMURO, T
HIGUCHI, S
HARADA, M
TAKAMURA, T
OTOMO, S
AIHARA, H
IKEKAWA, N
KOBAYASHI, T
机构
[1] TAISHO PHARMACEUT CO LTD, RES CTR, DEPT PHARMACOL, OMIYA, SAITAMA 330, JAPAN
[2] TOKYO COLL PHARM, HACHIOJI, TOKYO 19203, JAPAN
[3] IWAKI MEISEI UNIV, IWAKI 970, JAPAN
来源
BONE AND MINERAL | 1990年 / 9卷 / 02期
关键词
26,27-Hexafluoro-1,25-dihydroxyvitamin D[!sub]3[!/sub; Immobilization; Osteoporosis; Ovariectomy; Rat;
D O I
10.1016/0169-6009(90)90076-R
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of 26,27-hexafluoro-1,25-dihydroxyvitamin D3 (F6-1,25(OH)2D3) on experimental osteoporosis in the rat induced by a combination of immobilization and ovariectomy was evaluated. F6-1, 25(OH)2D3 increased the femur score and the photo-density. The administration of F6-1,25(OH)2D3 also significantly increased the dry weight, the ash weight and the ash content of the bone. Both F6-1,25(OH) 2D3 and 1α(OH)D3 showed a nearly dose-dependent effect and significant inhibition of the decrease of bone mass. Histomorphometry revealed a significant decrease of resorption by the administration of F6-1,25(OH)2D3. Bone formation rate in the F6-1,25(OH)2D3 treated group significantly decreased compared with the vehicle group. In conclusion, the pharmacological effective dose of F6-1, 25(OH)2D3 was considered to prevent the osteoporotic decrease of bone mass by suppressing the elevated bone turnover. © 1990.
引用
收藏
页码:101 / 109
页数:9
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