EVALUATION OF ROBOT AUTOMATED DRUG DISSOLUTION MEASUREMENTS

被引：29

作者：

PAPAS, AN ^{[1
]}

ALPERT, MY ^{[1
]}

MARCHESE, SM ^{[1
]}

FITZGERALD, JW ^{[1
]}

机构：

[1] BOSTON UNIV,DEPT CHEM,BOSTON,MA 02215

来源：

ANALYTICAL CHEMISTRY | 1985年 / 57卷 / 07期

关键词：

ROBOTS; INDUSTRIAL; -; Applications;

D O I：

10.1021/ac00284a051

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A controlled study was conducted to evaluate the feasibility of robotic automation of routine regulatory drug dissolution measurements. A commercially available laboratory robot system automated a number of dissolution analyses while concurrent manually acquired samples were analyzed by the same analytical method. The results were subjected to a statistical analysis of variance (ANOVA). After some small sources of systematic bias were eliminated, the results obtained by the robot were statistically indistinguishable from the manual results.

引用

页码：1408 / 1411

页数：4

共 12 条

[1] LONG-TERM CONTROLLED NAVEL ADMINISTRATION OF TESTOSTERONE
CHIEN, YW
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (08) : 1064 - 1067
[2] SINTERING TECHNIQUE FOR THE PREPARATION OF POLYMER MATRICES FOR THE CONTROLLED RELEASE OF MACROMOLECULES
COHEN, J
SIEGEL, RA
LANGER, R
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (08) : 1034 - 1037
[3] Cox D., 1978, PHARM TECHNOL, V2, P40
[4] COLLABORATIVE STUDY OF THE USP DISSOLUTION TEST FOR PREDNISONE TABLETS WITH APPARATUS-2
COX, DC
FURMAN, WB
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (05) : 670 - 676
[5] SYSTEMATIC-ERROR ASSOCIATED WITH APPARATUS-2 OF THE USP DISSOLUTION TEST .3. LIMITATIONS OF CALIBRATORS AND THE USP SUITABILITY TEST
COX, DC
FURMAN, WB
THORNTON, LK
MOORE, TW
JEFFERSON, EH
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (08) : 910 - 913
[6] SYSTEMATIC-ERROR ASSOCIATED WITH APPARATUS-2 OF THE USP DISSOLUTION TEST .5. INTERACTION OF 2 TABLETED PREDNISONE FORMULATIONS WITH GLASS AND PLASTIC VESSELS
COX, DC
FURMAN, WB
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (08) : 1125 - 1127
[7] GURBARG M, COMMUNICATION
[8] HANSON WA, 1982, HDB DISSOLUTION TEST
[9] KNAPP G, 1977, PHARM TECHNOL, V1, P12
[10] LEESON LJ, 1984, PHARMACOPEIAL FORUM, V10, P4103

← 1 2 →