T-CELL RECEPTOR-GAMMA VARIABLE GENE LOCUS POLYMORPHISM IN PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：7

作者：

CHAOUNI, I

LEFRANC, MP

DANGEAC, AD

ZANIN, C

PELLET, F

CLOT, J

COMBE, B

SANY, J

REME, T

机构：

[1] Inserm U291, Montpellier

来源：

ARTHRITIS AND RHEUMATISM | 1992年 / 35卷 / 07期

关键词：

D O I：

10.1002/art.1780350707

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. We sought new susceptibility markers for rheumatoid arthritis (RA) among the T cell receptor-gamma (TCR-gamma) genes. Methods. We analyzed restriction fragment length polymorphisms (RFLP) of the first variable subgroup of TCR-gamma genes in a group of French control subjects and a group of French RA patients. Results. No significant difference in Eco RI RFLP was found between the 2 study populations: Allele frequencies were virtually identical. There was no polymorphism using Hind III. Conclusion. These results exclude TCRV-gamma-I polymorphism as a disease susceptibility marker in RA.

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收藏

页码：756 / 760

页数：5

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