INACTIVATED HEPATITIS-A VACCINE - A SAFETY AND IMMUNOGENICITY STUDY IN HEALTH-PROFESSIONALS

被引：14

作者：

SANDMAN, L

DAVIDSON, M

KRUGMAN, S

机构：

[1] NYU,MED CTR,SCH MED,DEPT PEDIAT,NEW YORK,NY 10016

[2] NYU,SCH MED,DEPT MED,NEW YORK,NY 10016

[3] NYU,SCH MED,DEPT MICROBIOL,NEW YORK,NY 10016

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷

关键词：

D O I：

10.1093/infdis/171.Supplement_1.S50

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The safety and immunogenicity of an inactivated hepatitis A vaccine (HM175) were evaluated in 151 seronegative health professionals (age range, 21-65 years; mean, 30). A 720-ELISA unit dose was administered to 78 vaccinees at 0, 1, and 6 months and to 73 vaccinees at 0, 1, and 12 months. Seroconversion rates were 90% in both groups 1 month after the first inoculation and 99% and 100%, respectively, 1 month after the second inoculation. Geometric mean antibody titers (GMTs) 1 month after the third inoculation were highest in the group vaccinated at 0, 1, and 12 months. GMTs were higher in women than in men. The vaccine was well tolerated; the most frequent side effect was transient soreness at the site of inoculation. No serious adverse reactions were observed. Thus, HM175 inactivated hepatitis A vaccine is safe and highly immunogenic.

引用

页码：S50 / S52

页数：3

共 5 条

[1]

ANDRE FE, 1991, VIRAL HEPATITIS AND LIVER DISEASE, P85

[2] EFFECT OF VIRUS-STRAIN AND ANTIGEN DOSE ON IMMUNOGENICITY AND REACTOGENICITY OF AN INACTIVATED HEPATITIS-A VACCINE [J].