OXIDIZED LOW-DENSITY-LIPOPROTEIN IS CHEMOTACTIC FOR ARTERIAL SMOOTH-MUSCLE CELLS IN CULTURE

被引：76

作者：

AUTIO, I

JAAKKOLA, O

SOLAKIVI, T

NIKKARI, T

机构：

[1] Department of Biomedical Sciences, University of Tampere, Tampere

来源：

FEBS LETTERS | 1990年 / 277卷 / 1-2期

关键词：

ATHEROSCLEROSIS; OXIDIZED LOW-DENSITY LIPOPROTEIN; VASCULAR SMOOTH MUSCLE CELL; CHEMOTAXIS; MIGRATION;

D O I：

10.1016/0014-5793(90)80857-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of human native and Cu2+ -oxidized low-density lipoprotein (LDL) were tested on the migration of cultured bovine aortic smooth muscle cells (SMCs) in blind-well chambers. LDL oxidation was controlled by measuring the formation of conjugated dienes and lipid hydroperoxides, and by agarose gel electrophoresis. Oxidized LDL stimulated SMC migration, and the effect was dose-dependent up to 200-mu-g/ml. The stimulation was chemotactic in nature. Native LDL was without significant activity. The results suggest that oxidized LDL may contribute to the migration of medial SMCs into the intima during atherogenesis.

引用

页码：247 / 249

页数：3

共 16 条

[1]

AUTIO I, 1989, ARTERY, V16, P72

[2]

ELSAADANI M, 1989, J LIPID RES, V30, P627

[3] CONTINUOUS MONITORING OF INVITRO OXIDATION OF HUMAN LOW-DENSITY LIPOPROTEIN [J].