METABOLISM OF RADIOLABELED CHYLOMICRON LIPIDS IN INTACT AND HEPATECTOMIZED RATS

被引：2

作者：

BELCHER, JD

RUDEL, LL

WAITE, M

机构：

[1] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT BIOCHEM, WINSTON SALEM, NC 27103 USA

[2] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT COMPARAT MED, WINSTON SALEM, NC 27103 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1985年 / 81卷 / 01期

关键词：

D O I：

10.1016/0305-0491(85)90166-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intact rats removed more radiolabeled triacylglycerol cholesterol and cholesterol ester but not phosphatidylcholine (PC) in the first 6 min than hepatectomized rats. There was no difference between intact and hepatectomized rats in the transfer of radiolabeled chylomicron lipids to other lipoproteins. Specific radioactivity measurements demonstrated a net transfer of PC (intact and hepatectomized rats) and unesterified cholesterol (intact rats only) onto both the low density lipoprotein/high density lipoprotein-1 (LDL/HDL1) and HDL2 fractions. [3H]Fatty acids were rapidly incorporatd into blood cell phospholipids and into HDL and LDL cholesterol esters of both intact and hepatectomized rats. Substantial rearrangements of [3H]palmitate occurred during lipid uptake by liver.

引用

页码：87 / 96

页数：10

共 35 条

[1] METABOLISM OF CHYLE TRIGLYCERIDES IN LIVER .I. STUDIES ON MECHANISMS FOR LIVER UPTAKE OF INTRAVENOUSLY INJECTED GLYCEROL- AND FATTY ACID-LABELED CHYLE IN CARBOHYDRATE-FED RAT [J].