INSULIN-LIKE GROWTH-FACTOR-I ACTIONS ON STEROIDOGENESIS

被引：10

作者：

CHATELAIN, PG ^{[1
]}

AVALLET, MO ^{[1
]}

NICOLINO, M ^{[1
]}

LEJEUNE, H ^{[1
]}

CLARK, A ^{[1
]}

CHUZEL, F ^{[1
]}

PENHOAT, A ^{[1
]}

SAEZ, JM ^{[1
]}

机构：

[1] UNIV LYON 1, HOP DEBROUSSE, DEPT PEDIAT, F-69365 LYON, FRANCE

来源：

ACTA PAEDIATRICA | 1994年 / 83卷

关键词：

D O I：

10.1111/j.1651-2227.1994.tb13319.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The best evidence that insulin‐like growth factor I (IGF‐I) contributes to normal steroidogenesis comes from patients with growth hormone (GH) insensitivity syndrome due to deletion of the GH receptor gene. These patients have severe GH resistance and severe IGF‐I insufficiency, and present with markedly delayed puberty without gonadotrophin insufficiency. The same applies to patients with severe isolated GH insufficiency due to GH gene deletion, in whom GH treatment results in normalization of puberty and gonadal steroidogenesis. Delayed sexual maturation is also observed in GH‐deficient Snell dwarf mice. These observations strongly suggest that IGF‐I plays a role in the endocrine function and differentiation of the gonads. Copyright © 1994, Wiley Blackwell. All rights reserved

引用

页码：176 / 177

页数：2

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