EFFECT OF PEPTIDE YY (PYY) ON FOOD-ASSOCIATED CONFLICT

被引：22

作者：

HAGAN, MM

MOSS, DE

机构：

[1] Laboratory of Psychobiochemistry, Department of Psychology, University of Texas at El Paso, El Paso

来源：

PHYSIOLOGY & BEHAVIOR | 1995年 / 58卷 / 04期

关键词：

ANIMAL MODELS; ANXIETY; BULIMIA NERVOSA; CONFLICT; FOOD CHOICE; FOOT SHOCK; HYPERPHAGIA; PEPTIDE YY (PYY);

D O I：

10.1016/0031-9384(95)00100-W

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Peptide YY (PW) administered centrally in rats induces powerful overeating. PW also occurs endogenously in humans and is elevated in abstaining bulimic patients. To examine the effect of PW in an environment that parallels some aspects of bulimia, rats were tested in a paradigm associated with approach-avoidance behavior, choosing a preferred (sweet) food paired with shock, over regular food safe from shock. PW-treated rats chose to sustain shock to retrieve and consume the preferred food, at a significantly greater speed and quantity. The number of approaches that were met without retrieval of food due to anxiety after PW treatment indicates that PYY increased motivation towards feeding, rather than anxiolysis. This effect of PW in a model of conflict associated with food choice resembles aspects of bulimic binge-eating, which is characterized by the repetitive, rapid intake of food, despite anxiety associated with this behavior.

引用

页码：731 / 735

页数：5

共 19 条

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