A ROLE FOR CALCIUM RELEASE-ACTIVATED CURRENT (CRAC) IN CHOLINERGIC MODULATION OF ELECTRICAL-ACTIVITY IN PANCREATIC BETA-CELLS

被引：89

作者：

BERTRAM, R

SMOLEN, P

SHERMAN, A

MEARS, D

ATWATER, I

MARTIN, F

SORIA, B

机构：

[1] NIDDKD,CELL BIOL & GENET LAB,BETHESDA,MD 20892

[2] JOHNS HOPKINS UNIV,DEPT BIOMED ENGN,BALTIMORE,MD 21205

[3] UNIV ALICANTE,DEPT PHYSIOL,E-03080 ALACANT,SPAIN

[4] UNIV ALICANTE,INST NEUROSCI,E-03080 ALACANT,SPAIN

来源：

BIOPHYSICAL JOURNAL | 1995年 / 68卷 / 06期

关键词：

D O I：

10.1016/S0006-3495(95)80414-5

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current.

引用

页码：2323 / 2332

页数：10