Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers

被引：9

作者：

Barker, A

Jones, R

Simpson, P

Wesnes, K

机构：

[1] ST MARTINS HOSP, RES INST CARE ELDERLY, BATH, AVON, ENGLAND

[2] COGNIT DRUG RES LTD, READING, BERKS, ENGLAND

来源：

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | 1995年 / 10卷 / 12期

关键词：

memory; ageing; diagnosis; Alzheimer's disease; dementia;

D O I：

10.1002/gps.930101211

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

There are theoretical grounds for believing that scopolamine-induced cognitive deficit may be predictive of future cognitive decline. In the present study, 22 healthy elderly volunteers were reassessed 3 years after a scopolamine challenge. Although there was little overall change in mean cognitive test scores over time, in two out of 10 tests scopolamine-induced decrement was related to subsequent decline.

引用

页码：1059 / 1062

页数：4

共 16 条

[1]

[Anonymous], 1990, DEMENT GERIATR COGN, DOI DOI 10.1159/000107143

[2] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].