EXTRACTION AND SPECTROPHOTOMETRIC DETERMINATION OF NEOMYCIN SULFATE IN PHARMACEUTICAL ORAL SUSPENSIONS

被引：7

作者：

MARQUES, MRC

HACKMANN, ERM

SAITO, T

机构：

[1] Faculdade de Cie'ncias Farmaceuticas, Universidade de Sao Paulo, Caixa Postal 30786

来源：

ANALYTICAL LETTERS | 1990年 / 23卷 / 06期

关键词：

extraction; neomycin sulfate; oral suspension; spectrophotometry;

D O I：

10.1080/00032719008053442

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The conditions of neomycin extraction were studied in pharmaceutical oral suspensions to permit its determination by spectrophotometry after reaction with 2, 4-dinitrofluorobenzene. The best recovery of neomycin was obtained with centrifugation employing water as the extraction agent. The spectrophotometric analysis was carried out in 0.02 M borate buffer (pH 9.0), under ambient conditions after 50 minutes of reaction. The absorbance of the yellow product was measured at 365 nm. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：1005 / 1016

页数：12

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[2]

GHAZY FS, 1984, PHARMAZIE, V39, P821

[3]

GOODMAN LS, 1985, PHARMACOL BASIS THER, P1150

[4]

HARRIS WA, 1971, AUSTR J PHARM, V52, P569