BIOCONVERSION AND BIOSYNTHESIS OF 16-MEMBERED MACROLIDE ANTIBIOTICS .32. AMMONIUM-IONS SUPPRESS THE AMINO-ACID-METABOLISM INVOLVED IN THE BIOSYNTHESIS OF PROTYLONOLIDE IN A MUTANT OF STREPTOMYCES-FRADIAE

被引：28

作者：

OMURA, S ^{[1
]}

TAKI, A ^{[1
]}

MATSUDA, K ^{[1
]}

TANAKA, Y ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1984年 / 37卷 / 11期

关键词：

D O I：

10.7164/antibiotics.37.1362

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：1362 / 1369

页数：8

共 10 条

[1]

BALTZ RH, 1981, ANTIMICROB AGENTS CH, V20, P215

[2] INCORPORATION OF AMINO-ACID DERIVED CARBON INTO TYLACTONE BY STREPTOMYCES-FRADIAE GS14 [J].

DOTZLAF, JE ;

METZGER, LS ;

FOGLESONG, MA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 25 (02) :216-220

[3]

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[4] BIOSYNTHESIS OF THE MACROLIDE ANTIBIOTIC TYLOSIN - ORIGIN OF THE OXYGEN-ATOMS IN TYLACTONE [J].

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ROBINSON, JA ;

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JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1983, (22) :1337-1340

[5]

OMURA S, 1976, BIOORG CHEM, V5, P451

[6] BIOCONVERSION AND BIOSYNTHESIS OF 16-MEMBERED MACROLIDE ANTIBIOTICS .29. EFFECT OF AMMONIUM ION, INORGANIC-PHOSPHATE AND AMINO-ACIDS ON THE BIOSYNTHESIS OF PROTYLONOLIDE, A PRECURSOR OF TYLOSIN AGLYCONE [J].

OMURA, S ;

TANAKA, Y ;

MAMADA, H ;

MASUMA, R .

JOURNAL OF ANTIBIOTICS, 1984, 37 (05) :494-502

[7] STUDIES ON BIOSYNTHESIS OF 16-MEMBERED MACROLIDE ANTIBIOTICS USING C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].

OMURA, S ;

TAKESHIMA, H ;

NAKAGAWA, A ;

MIYAZAWA, J ;

PIRIOU, F ;

LUKACS, G .

BIOCHEMISTRY, 1977, 16 (13) :2860-2866

[8] VALINE AS A PRECURSOR OF NORMAL-BUTYRATE UNIT IN THE BIOSYNTHESIS OF MACROLIDE AGLYCONE [J].

OMURA, S ;

TSUZUKI, K ;

TANAKA, Y ;

SAKAKIBARA, H ;

AIZAWA, M ;

LUKACS, G .

JOURNAL OF ANTIBIOTICS, 1983, 36 (05) :614-616

[9]

OMURA S, 1975, TETRAHEDRON LETT, P4503

[10]

OMURA S, 1980, CHEM PHARM B, V29, P1963

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