EFFICACY OF AMPICILLIN VERSUS TRIMETHOPRIM-SULFAMETHOXAZOLE IN A MOUSE MODEL OF LETHAL ENTEROCOCCAL PERITONITIS

被引：26

作者：

CHENOWETH, CE ^{[1
]}

ROBINSON, KA ^{[1
]}

SCHABERG, DR ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT INTERNAL MED,DIV INFECT DIS,ANN ARBOR,MI 48109

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 09期

关键词：

D O I：

10.1128/AAC.34.9.1800

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lethal enterococcal peritonitis in mice was used to compare trimethoprim-sulfamethoxazole (TMP-SMX) therapy with ampicillin therapy. Peritoneal fluid showed a 103-CFU decrease in enterococci with ampicillin compared with TMP-SMX. Mortality of the untreated mice was 100%, compared with 40% for ampicillin and 95% for TMP-SMX, despite adequately measured levels in serum and peritoneal fluid.

引用

页码：1800 / 1802

页数：3

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