STUDIES ON A SYNTHESIS OF (RS)-MEVALONIC ACID LACTONE

被引：20

作者：

BARDSHIRI, E

SIMPSON, TJ

SCOTT, AI

SHISHIDO, K

机构：

[1] UNIV EDINBURGH, DEPT CHEM, EDINBURGH EH9 3JJ, MIDLOTHIAN, SCOTLAND

[2] TEXAS A&M UNIV, DEPT CHEM, COLLEGE STN, TX 77843 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1984年 / 08期

关键词：

D O I：

10.1039/p19840001765

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Full details of a high yielding synthesis of mevalonic acid lactone which is of particular value in the preparation of 3- and/or 3''-labeled compounds are described. The key step, conversion of 3-hydroxy-3-methylpentane-1,5-diotic acid into 3-hydroxy-3-methylpentane-1,5-dioic anhydride using acetic anhydride, has been fully investigated, and an additional method using acetyl chloride and triethylamine is described.

引用

页码：1765 / 1767

页数：3

共 15 条

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