HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC EVALUATION OF 2-(ALPHA-THENOYLTHIO)PROPIONYLGLYCINE AND ITS 2 METABOLITES IN BIOLOGICAL-FLUIDS

被引:2
作者
MARZO, A [1 ]
MARTELLI, EA [1 ]
BRUNO, G [1 ]
NAVA, D [1 ]
MIGNOT, A [1 ]
VIDAL, R [1 ]
LEFEBVRE, MA [1 ]
机构
[1] CTR ETUD & RECH PHARM CLIN,F-86280 ST BENOIT,FRANCE
来源
JOURNAL OF CHROMATOGRAPHY | 1991年 / 536卷 / 1-2期
关键词
D O I
10.1016/S0021-9673(01)89266-9
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A high-performance liquid chromatographic (HPLC) method for determining 2-(alpha-thenoylthio)propionylglycine (TTPG) and its two main metabolites, thiophenecarboxylic acid and thiopronine, in biological samples was developed. TTPG and its metabolites were extracted by solvent partition and then determined by reversed-phase HPLC with UV detection at 245, 295 and 360 nm. This procedure was validated in order to allow the assay of these compounds in plasma and urine samples with sufficiently low detection limits (50 ng/ml for TTPG and TCA and 100 ng/ml for thiopronine) and with good linearity within the concentration range investigated. It was applied to a comprehensive pharmacokinetic investigation of TTPG in healthy volunteers.
引用
收藏
页码:327 / 335
页数:9
相关论文
共 8 条
[1]  
AIACHE JM, 1982, DOSAGE ALPHA THENOYL
[2]  
BAEYENS W, 1988, ANAL LETT, V21, P741
[3]  
DURANTI I, 1985, FARM ED PRAT, V10, P347
[4]  
HAMMER R, 1978, ARZNEIMITTEL-FORSCH, V28-1, P899
[5]  
JAUCH R, 1978, ARZNEIMITTEL-FORSCH, V28-1, P904
[6]   DETERMINATION OF N-ACETYLCYSTEINE, INTACT AND OXIDIZED, IN PLASMA BY COLUMN LIQUID-CHROMATOGRAPHY AND POSTCOLUMN DERIVATIZATION [J].
JOHANSSON, M ;
WESTERLUND, D .
JOURNAL OF CHROMATOGRAPHY, 1987, 385 :343-356
[7]  
KAGEDAL B, 1982, J CHROMATOGR, V229, P409
[8]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY FOR N-ACETYLCYSTEINE IN PLASMA AND URINE [J].
LEWIS, PA ;
WOODWARD, AJ ;
MADDOCK, J .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (07) :996-998