BETA-ENDORPHIN DECLINE IN LATE LUTEAL PHASE DYSPHORIC DISORDER

被引:32
作者
GIANNINI, AJ [1 ]
MARTIN, DM [1 ]
TURNER, CE [1 ]
机构
[1] OHIO STATE UNIV,COLUMBUS,OH 43210
关键词
D O I
10.2190/JRQJ-XTX9-CQPF-HD70
中图分类号
R749 [精神病学];
学科分类号
100205 [精神病与精神卫生学];
摘要
The β-endorphin hypothesis of late luteal phase dysphoric disorder (premenstrual syndrome or L2D2) was tested. Twenty-two PMS patients were compared to twenty-two controls. Levels of β-endorphin, ACTH, FSH, LH, cortisol, prolactin and TRH were measured on the first and twentieth days after menses. PMS subjects exhibited a significantly greater drop in the opiate, β-endorphin, (p < .001) than controls. No relationship or significant e was seen with the other hormones/transmitters tested. The symptoms of PMS may be due to noradrenergic rebound following β-endorphin decline. Symptomatic and pharmacological morphine withdrawal and manic phase of bipolar disorder are discussed as possible models for L2D2.
引用
收藏
页码:279 / 284
页数:6
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