ASSESSMENT OF ANTI-HIV ACTIVITY OF SOME BENZIMIDAZOLYLTHIAZOLES

被引：15

作者：

BADAWEY, EAM

HAZZAA, AA

RIDA, SM

FAHMY, HTY

机构：

[1] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 09期

关键词：

D O I：

10.1002/ardp.19923250908

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzimidazolylthiazoles 2 were synthesized by condensing 1H-Benzimidazole-2-acetonitrile (1) with sulphur and isothiocyanates. The syntheses of the Schiff bases 3, thioureas 4, and thiazolopyrimido[1,6-a]benzimidazoles 5 and 6 are also described. Seven compounds were evaluated in vitro against human HIV, however, no significant activity was observed with any of these compounds.

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页码：565 / 567

页数：3

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