PHOSPHOLIPASE-C ACTIVITY IN CEREBROSPINAL-FLUID FOLLOWING SUBARACHNOID HEMORRHAGE RELATED TO BRAIN-DAMAGE

被引：13

作者：

NAKASHIMA, T ^{[1
]}

TAKENAKA, K ^{[1
]}

NISHIMURA, Y ^{[1
]}

ANDOH, T ^{[1
]}

SAKAI, N ^{[1
]}

YAMADA, H ^{[1
]}

BANNO, Y ^{[1
]}

OKANO, Y ^{[1
]}

NOZAWA, Y ^{[1
]}

机构：

[1] GIFU UNIV, SCH MED, DEPT BIOCHEM, GIFU 500, JAPAN

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1993年 / 13卷 / 02期

关键词：

BRAIN DAMAGE; CEREBROSPINAL FLUID; NEURON-SPECIFIC ENOLASE; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE-C; SUBARACHNOID HEMORRHAGE;

D O I：

10.1038/jcbfm.1993.31

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phosphoinositide-specific phospholipase C (PLC) activities were measured in CSF from patients after subarachnoid hemorrhage (SAH). Their PLC activities were significantly higher than those in control CSF. Moreover, there was an obvious correlation between the PLC activity in CSF collected on day 3 and the preoperative clinical grade. The PLC activity was also closely correlated with the level of neuron-specific enolase as a marker of brain damage. Furthermore, the PLC activities were partially purified from CSF of patients after SAH and were immunologically identified to be PLCbeta, PLCgamma, and PLCdelta. These results suggest that PLCs are released into the CSF from brain tissue in conjunction with the initial hemorrhage and that their activity may reflect the extent of brain damage.

引用

页码：255 / 259

页数：5

共 22 条

[1]

BANNO Y, 1988, J BIOL CHEM, V263, P11459

[2] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION [J].