FACILE SYNTHESIS OF (+/-)-GALANTHAMINE AND (-)-GALANTHAMINE

被引：38

作者：

SZEWCZYK, J

WILSON, JW

LEWIN, AH

CARROLL, FI

机构：

[1] Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina, 27709

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 01期

关键词：

D O I：

10.1002/jhet.5570320132

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Amarylidacea alkaloid galanthamine (1a) is an acetylcholinesterase inhibitor that has been evaluated as a potential agent for the treatment of Alzheimer's disease. We report a very efficient synthesis of (+/-)-galanthamine [(+/-)-1a] from readily available isovanillin and tyramine. We have separated racemic galanthamine into its diastereoisomeric (1S)-camphanate esters and obtained both natural (-)- and unnatural (+)-galanthamine by lithium aluminum hydride removal of the acyl group.

引用

页码：195 / 199

页数：5

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