SYNTHESIS AND ANTIVIRAL EVALUATION OF HYDANTOIN ANALOGS OF AZT

被引：26

作者：

ELBARBARY, AA

KHODAIR, AI

PEDERSEN, EB

机构：

[1] Department of Chemistry, Odense University, Odense M

[2] Retrovirus Laboratory, Department of Virology, Statens Serumsinstitut, Copenhagen, DK-2300

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 10期

关键词：

D O I：

10.1002/ardp.19943271010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3'-Azidonucleosides 4 have been synthesized by condensation of silylated (Z)-5-ethylidenehydantoin and (Z)-5-benzylidenehydantoin with methyl 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pentofuranoside (3). The nucleosides 4 were deblocked on treatment with tetrabutylammonium fluoride. The ethylidene group isomerized from Z to E configuration during the nucleoside synthesis. The new nucleosides did not show any appreciable activities against HIV-1 or HSV-1.

引用

页码：653 / 655

页数：3

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