THE IMPORTANCE OF LIPOSOMES AS MODELS AND TOOLS IN THE UNDERSTANDING OF PHOTOSENSITIZATION MECHANISMS

被引：49

作者：

HOEBEKE, M

机构：

[1] Laboratory of Experimental Physics, Institute of Physics, B5, University of Liège

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1995年 / 28卷 / 03期

关键词：

LIPOSOMES; PHOTOSENSITIZATION; PHOTODYNAMIC THERAPY;

D O I：

10.1016/1011-1344(95)07132-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in phototherapy. Liposomes are simple vesicles in which an aqueous phase is enclosed by a phospholipidic membrane. They are suitable models mimicking specific situations occurring in vivo and they allow study of the influence of physicochemical, photobiological and biochemical factors on the uptake of photosensitizers by tissues, their mechanisms of action and the subsequent photoinduced tumor necrosis. Moreover, solubilization of the sensitizer into the bilayer seems to improve its tumoral selectivity and its photodynamic efficiency.

引用

页码：189 / 196

页数：8

共 92 条

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