RETINAL TOXICITY OF INTRAVITREAL GENTAMICIN

被引：41

作者：

BROWN, GC

EAGLE, RC

SHAKIN, EP

GRUBER, M

ARBIZIO, VV

机构：

[1] THOMAS JEFFERSON UNIV,WILLS EYE HOSP,SCH MED,PATHOL SERV,PHILADELPHIA,PA 19107

[2] THOMAS JEFFERSON UNIV,WILLS EYE HOSP,SCH MED,RETINA VASC UNIT SERV,PHILADELPHIA,PA 19107

来源：

ARCHIVES OF OPHTHALMOLOGY | 1990年 / 108卷 / 12期

关键词：

D O I：

10.1001/archopht.1990.01070140094037

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The short- and long-term effects of a 10-mg dose of intravitreal gentamicin were studied in the subhuman primate eye with regard to the changes in clinical appearance, fluorescein angiography, electroretinography, histopathologic finding, and electron microscopy. The gentamicin produced retinal whitening with a cherry-red spot, generalized vascular incompetence, diffuse retinal necrosis, thrombosis of the large retinal blood vessels, widespread loss of the retinal capillary pericytes and endothelial cells, and a rapid extinction of the electroretinogram. © 1990, American Medical Association. All rights reserved.

引用

页码：1740 / 1744

页数：5

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