AMBIDENT BEHAVIOR OF THE NEW VITAMIN METHOXATIN (COFACTOR PQQ) TOWARDS METALS - COORDINATIVE STABILIZATION OF THE PYRROLIDE FORM AND THE SEMIQUINONE FORM

被引：38

作者：

SCHWEDERSKI, B

KASACK, V

KAIM, W

ROTH, E

JORDANOV, J

机构：

[1] UNIV STUTTGART,INST ANORGAN CHEM,PFAFFENWALDRING 55,W-7000 STUTTGART 80,GERMANY

[2] CEN,SERV PHYS,DEPT RECH FONDAMENTALE,F-38041 GRENOBLE,FRANCE

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 01期

关键词：

D O I：

10.1002/anie.199000781

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biochemical function of the o‐quinonoid “new vitamin” methoxatin (Cofactor PQQ) is coupled with the formation of the semiquinone form and possibly also with metal coordination. In contrast to “hard” copper(II) fragments, the “soft” [Ru(bpy)2]2⊕, which is capable of π‐back bonding, coordinates via the two o ‐quinone oxygen atoms of the methoxatin; both the semiquinoid intermediate as well as the form with deprotonated pyrrole ring are thereby stabilized and shifted into a physiologically relevant potential‐ and pH‐range. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

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页码：78 / 80

页数：3

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