THE SYNTHESIS OF 1,3,4-THIADIAZOL-2-YLCYANAMIDE SODIUM, A POTENTIALLY USEFUL ANTIINFLUENZA AGENT AND ITS [5-C-14] AND [UL-(C-13)3] ISOTOPOMERS

As an aid to the study of the metabolism and disposition of LY217896 in laboratory animals and humans, C-14-labeled material was prepared utilizing formic-[C-14] acid as the starting material. Uniformly labeled LY217896-[C-13] was also synthesized for use in metabolite identification. Formic acid, cyanogen bromide, and potassium cyanide which were >99% isotopically enriched with C-13 were utilized; once the appropriate starting materials were synthesized, the synthesis of the C-13 and C-14-labeled materials were parallel.