SEQUENCE AND EXPRESSION OF A METABOTROPIC GLUTAMATE RECEPTOR

被引：1053

作者：

MASU, M

TANABE, Y

TSUCHIDA, K

SHIGEMOTO, R

NAKANISHI, S

机构：

[1] KYOTO UNIV,FAC MED,INST IMMUNOL,KYOTO 606,JAPAN

[2] KYOTO UNIV,FAC MED,DEPT MORPHOL BRAIN SCI,KYOTO 606,JAPAN

来源：

NATURE | 1991年 / 349卷 / 6312期

关键词：

D O I：

10.1038/349760a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.

引用

页码：760 / 765

页数：6

共 36 条

[1] ANGERER LM, 1987, METHOD ENZYMOL, V152, P649
[2] THE ROLE OF CHARGED AMINO-ACIDS IN THE LOCALIZATION OF SECRETED AND MEMBRANE-PROTEINS
BOYD, D
BECKWITH, J
[J]. CELL, 1990, 62 (06) : 1031 - 1033
[3] THE USE OF XENOPUS OOCYTES FOR THE STUDY OF ION CHANNELS
DASCAL, N
[J]. CRC CRITICAL REVIEWS IN BIOCHEMISTRY, 1987, 22 (04): : 317 - 387
[4] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF THE INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN-P400
FURUICHI, T
YOSHIKAWA, S
MIYAWAKI, A
WADA, K
MAEDA, N
MIKOSHIBA, K
[J]. NATURE, 1989, 342 (6245) : 32 - 38
[5] A PERTUSSIS TOXIN SENSITIVE G-PROTEIN IN HIPPOCAMPAL LONG-TERM POTENTIATION
GOH, JW
PENNEFATHER, PS
[J]. SCIENCE, 1989, 244 (4907) : 980 - 983
[6] CLONING BY FUNCTIONAL EXPRESSION OF A MEMBER OF THE GLUTAMATE RECEPTOR FAMILY
HOLLMANN, M
OSHEAGREENFIELD, A
ROGERS, SW
HEINEMANN, S
[J]. NATURE, 1989, 342 (6250) : 643 - 648
[7] SYNTHESIS AND PROCESSING OF ASPARAGINE-LINKED OLIGOSACCHARIDES
HUBBARD, SC
IVATT, RJ
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1981, 50 : 555 - 583
[8] AUTORADIOGRAPHIC IMAGING OF PHOSPHOINOSITIDE TURNOVER IN THE BRAIN
HWANG, PM
BREDT, DS
SNYDER, SH
[J]. SCIENCE, 1990, 249 (4970) : 802 - 804
[9] PERTUSSIS TOXIN SUPPRESSES LONG-TERM POTENTIATION OF HIPPOCAMPAL MOSSY FIBER SYNAPSES
ITO, I
OKADA, D
SUGIYAMA, H
[J]. NEUROSCIENCE LETTERS, 1988, 90 (1-2) : 181 - 185
[10] LONG-TERM DEPRESSION
ITO, M
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1989, 12 : 85 - 102

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