A CROSS-SECTIONAL STUDY OF ECHOCARDIOGRAPHIC INDEXES, TREADMILL EXERCISE CAPACITY AND MICROVASCULAR COMPLICATIONS IN NIGERIAN PATIENTS WITH HYPERTENSION ASSOCIATED WITH DIABETES-MELLITUS

被引：13

作者：

BABALOLA, RO ^{[1
]}

AJAYI, AA ^{[1
]}

机构：

[1] OBAFEMI AWOLOWO UNIV,FAC HLTH SCI,IFE,NIGERIA

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 10期

关键词：

DIABETES-MELLITUS; HYPERTENSION; ECHOCARDIOGRAPHY; AFRICANS; EXERCISE TOLERANCE; PROTEINURIA;

D O I：

10.1111/j.1464-5491.1992.tb01728.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Associations between hypertension and cardiovascular complications of diabetes mellitus in Nigerians, were examined in a cross-sectional study. 20 hypertensive-diabetic patients, 16 hypertensive patients, 10 non-hypertensive diabetic patients and 10 age- and sex-matched healthy controls, underwent M-mode and cross-sectional echocardiography, and Bruce-protocol treadmill exercise performance. Left ventricular (LV) mass indices (+/- SD) were significantly higher in hypertensive patients (164 +/- 12gm-2), diabetic (158 +/- 17gm-2) and hypertensive diabetic patients (125 +/- 129gm-2) compared with normal controls (111 +/- 17gm-2) p < 0.01. However, the LV mass index in the hypertensive-diabetic patients was significantly less than in hypertensive (p < 0.05) or normotensive diabetic patients (p < 0.05). Systolic cardiac contractility measured as fractional fibre shortening, was preserved in the hypertensive patients (24 +/- 4%) compared with the healthy controls (23 +/- 4%), but was depressed in diabetic patients (19 +/- 3%) and to a greater extent in the hypertensive-diabetic patients (15 +/- 4% p < 0.01). Treadmill exercise tolerance time was reduced independently in hypertension (309 +/- 73 seconds) or diabetes (321 +/- 119 seconds), p < 0.05, but was further impaired in hypertensive-diabetic patients (289 +/- 110 seconds) p < 0.01 compared to the healthy controls (490 +/- 156 seconds). The patients with hypertension and diabetes had a greater degree of proteinuria (p < 0.001) and a higher frequency of retinopathy (p < 0.001), in comparison to those with hypertension or diabetes alone.

引用

页码：899 / 903

页数：5

共 30 条

[1] Yudkin JS., Factors influencing threshold and choice of treatment for hypertension in NIDDM, Diabetes Care, 14, pp. 27-32, (1991)
[2] Akinkugbe OO., World epidemiology of hypertension in blacks, Hypertension in Blacks, pp. 3-16, (1985)
[3] Reaven GM., Banting Lecture: role of insulin resistance in human disease, Diabetes, 37, pp. 1595-1607, (1988)
[4] Osuntokun BO., Hypertension in Nigerian Diabetics: a study of 832 patients, Afr J Med Sci, 2, pp. 322-326, (1972)
[5] Kannel WB, McCee DL., Diabetes and cardiovascular risk factors: the Framingham Study, Circulation, 59, pp. 8-13, (1979)
[6] Jarrett RJ, Shipley MJ., Mortality and associated risk factors in diabetics, Acta Endocrinol, pp. 21-26, (1985)
[7] Fuller JH, Shipley MJ, Rose G., Jarret RJ, Keen H., Mortality from coronary artery disease and stroke in relation to the degree of glycaemia: the Whitehall study, Br Med J, 287, pp. 867-870, (1983)
[8] Pacy PJ, Dobson PM, Beevers M., Fletcher RF, Taylor KG., Prevalence of hypertension in white, black and Asian Diabetics in a district hospital diabetic clinic, Diabetic Med, 2, pp. 125-130, (1985)
[9] Dunn FG, Oigman W., Sundgaard-Rise K., Messerli FH, Ventura H., Reisin E., Frolich ED., Racial differences in cardiac adaptation to essential hypertension determined by echocardiography indices, J Am Coll Cardiol, 1, pp. 1348-1351, (1983)
[10] Frolich ED, Messerli FH, Dunn FG, Oigman W., Ventura HO, Sundgaard-Rise K., Greater renal involvement in black hypertensives with essential hypertension. A comparison of systemic and renal haemodynamics in black and white patients, Mineral Electrolyte Metals, 10, pp. 173-177, (1984)

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