EFFECTS OF BRADYKININ RECEPTOR AGONISTS, AND CAPTOPRIL AND THIORPHAN IN FERRET ISOLATED TRACHEA - EVIDENCE FOR BRADYKININ GENERATION IN-VITRO

被引：5

作者：

FARMER, SG ^{[1
]}

BROOM, T ^{[1
]}

DESIATO, MA ^{[1
]}

机构：

[1] ZENECA PHARMACEUT GRP, PULM PHARMACOL, B1124, 1800 CONCORD PIKE, WILMINGTON, DE 19897 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 03期

关键词：

BRADYKININ RECEPTOR ANTAGONIST; BRADYKININ BIOSYNTHESIS; TRACHEA; SMOOTH MUSCLE; AIRWAY; CAPTOPRIL; THIORPHAN;

D O I：

10.1016/0014-2999(94)90659-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bradykinin B-2 receptor agonists, but not a B-1 receptor agonist, were potent spasmogens of ferret isolated trachea. Bradykinin-induced contractions were unaffected by several pharmacological agents, indicating a direct effect on airway smooth muscle B-2 receptors. Captopril plus thiorphan caused contractions in approximately 70% of preparations that were abolished by B-2 receptor antagonists, but not by B-1 receptor antagonist. Thus, ferret tracheal tissues appear capable of releasing and degrading kinins in vitro. Inhibition of peptide degradation with captopril and thiorphan may allow the endogenous kinins to accumulate in concentrations sufficient to elicit tracheal contraction via activation of B-2 receptors.

引用

页码：309 / 313

页数：5

共 14 条

[1] KININS ARE GENERATED IN NASAL SECRETIONS DURING INFLUENZA-A INFECTIONS IN FERRETS [J].

BARNETT, JKC ;

CRUSE, LW ;

PROUD, D .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (01) :162-166

[2]

BUSSE R, 1991, N-S ARCH PHARMACOL, V344, P126

[3]

DUSSER DJ, 1988, J PHARMACOL EXP THER, V244, P531

[4]

FARMER SG, 1989, MOL PHARMACOL, V36, P1

[5] ROLE OF KININS IN AIRWAY DISEASES [J].

FARMER, SG .

IMMUNOPHARMACOLOGY, 1991, 22 (01) :1-20

[6]

FARMER SG, 1992, ANNU REV PHARMACOL, V32, P511

[7]

FARMER SG, 1992, BRIT J PHARMACOL, V107, pP31

[8]

FARMER SG, 1992, BRIT J PHARMACOL, V107, pP32

[9] MODULATION OF BRADYKININ RESPONSES IN AIRWAY SMOOTH-MUSCLE BY EPITHELIAL ENZYMES [J].

FROSSARD, N ;

STRETTON, CD ;

BARNES, PJ .

AGENTS AND ACTIONS, 1990, 31 (3-4) :204-209

[10]

FULLER RW, 1987, AM REV RESPIR DIS, V135, P176

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