MORPHINE SULFATION IN CHILDREN

被引：21

作者：

CHOONARA, I

EKBOM, Y

LINDSTROM, B

RANE, A

机构：

[1] NATL BOARD HLTH & WELF,DEPT DRUGS,UPPSALA,SWEDEN

[2] AKAD HOSP UPPSALA,DIV CLIN PHARMACOL,S-75185 UPPSALA,SWEDEN

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 30卷 / 06期

关键词：

D O I：

10.1111/j.1365-2125.1990.tb05458.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolism of morphine was studied in nine children and seven preterm neonates receiving a continuous infusion of morphine. All the neonates and three children had detectable concentrations of morphine‐3‐ sulphate (M3S) in urine. None of the neonates or the children had detectable concentrations of morphine‐6‐sulphate (M6S) in urine. None of the children had detectable concentrations of M3S in plasma. The M3S/morphine ratios were significantly higher in neonates than children (P less than 0.01), suggesting that morphine sulphation decreases after the neonatal period. The amount of M3S formed, even in neonates, is low suggesting that this is a minor metabolic pathway. 1990 The British Pharmacological Society

引用

页码：897 / 900

页数：4

共 26 条

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