STAUROSPORINE BOTH ACTIVATES AND INHIBITS SERINE THREONINE KINASES IN HUMAN PLATELETS

被引：38

作者：

KOCHER, M ^{[1
]}

CLEMETSON, KJ ^{[1
]}

机构：

[1] UNIV BERN,THEODOR KOCHER INST,FREIESTR 1,POB 99,CH-3012 BERN,SWITZERLAND

来源：

BIOCHEMICAL JOURNAL | 1991年 / 275卷

关键词：

D O I：

10.1042/bj2750301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of staurosporine on a selection of protein kinases were investigated with thrombin-stimulated and control human blood platelets. The results demonstrate that staurosporine (1-mu-M) can lead to activation of certain protein kinases in intact platelets and has a general inhibitory effect on the renaturable protein kinases in vitro. New candidates for protein kinases involved in signal transduction are identified.

引用

页码：301 / 306

页数：6

共 32 条

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