LIMITED SEQUENCE DIVERGENCE OF HTLV-I OF INDIAN HAM/TSP PATIENTS FROM A PROTOTYPE JAPANESE ISOLATE

被引：23

作者：

HASHIMOTO, K

LALKAKA, J

FUJISAWA, JI

SINGHAL, BS

MACHIGASHIRA, K

KUBOTA, R

SUEHARA, M

OSAME, M

YOSHIDA, M

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT CELLULAR & MOLEC BIOL,MINATO KU,TOKYO 108,JAPAN

[2] BOMBAY HOSP & MED RES CTR,INST MED SCI,DEPT NEUROL,BOMBAY,INDIA

[3] KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 3,KAGOSHIMA 890,JAPAN

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1993年 / 9卷 / 06期

关键词：

D O I：

10.1089/aid.1993.9.495

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nucleotide sequences of two HTLV-I proviruses isolated from Indian patients with HAM/TSP were analyzed. The sequence data of the env, pX, and LTR regions showed 98-99% homologies with the prototype HTLV-I, ATK-1, isolated from a Japanese ATL patient, indicating that HTLV-I isolates in India and Japan are similar, with minor variations. However, certain small sequences of noncoding regions in the pX and LTR showed differences of 6.1 and 7.2 %, respectively, thus the conclusion could vary depending on the regions and length of the sequences used for comparison.

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页码：495 / 498

页数：4

相关论文

共 21 条

[1]

ADVANI SH, 1987, INDIAN J MED RES, V86, P218

[2] SEQUENCE VARIANTS OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I FROM PATIENTS WITH TROPICAL SPASTIC PARAPARESIS AND ADULT T-CELL LEUKEMIA DO NOT DISTINGUISH NEUROLOGICAL FROM LEUKEMIC ISOLATES [J].

DAENKE, S ;

NIGHTINGALE, S ;

CRUICKSHANK, JK ;

BANGHAM, CRM .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1278-1282

[3] A TRANSCRIPTIONAL ENHANCER SEQUENCE OF HTLV-I IS RESPONSIBLE FOR TRANSACTIVATION MEDIATED BY P40X OF HTLV-I [J].

FUJISAWA, J ;

SEIKI, M ;

SATO, M ;

YOSHIDA, M .

EMBO JOURNAL, 1986, 5 (04) :713-718

[4]

GESSAIN A, 1985, LANCET, V2, P407

[5] HIGHLY DIVERGENT MOLECULAR VARIANTS OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I FROM ISOLATED POPULATIONS IN PAPUA-NEW-GUINEA AND THE SOLOMON-ISLANDS [J].

GESSAIN, A ;

YANAGIHARA, R ;

FRANCHINI, G ;

GARRUTO, RM ;

JENKINS, CL ;

AJDUKIEWICZ, AB ;

GALLO, RC ;

GAJDUSEK, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7694-7698

[6] ADULT T-CELL LEUKEMIA - ANTIGEN IN AN ATL CELL-LINE AND DETECTION OF ANTIBODIES TO THE ANTIGEN IN HUMAN-SERA [J].

HINUMA, Y ;

NAGATA, K ;

HANAOKA, M ;

NAKAI, M ;

MATSUMOTO, T ;

KINOSHITA, KI ;

SHIRAKAWA, S ;

MIYOSHI, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6476-6480

[7] MOLECULAR-CLONING AND COMPLETE NUCLEOTIDE-SEQUENCE OF AN ADULT T-CELL LEUKEMIA-VIRUS HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I (ATLV HTLV-I) ISOLATE OF CARIBBEAN ORIGIN - RELATIONSHIP TO OTHER MEMBERS OF THE ATLV HTLV-I SUBGROUP [J].

MALIK, KTA ;

EVEN, J ;

KARPAS, A .

JOURNAL OF GENERAL VIROLOGY, 1988, 69 :1695-1710

[8] A SINGLE SPECIES OF PX MESSENGER-RNA OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I ENCODES TRANSACTIVATOR P40X AND 2 OTHER PHOSPHOPROTEINS [J].

NAGASHIMA, K ;

YOSHIDA, M ;

SEIKI, M .

JOURNAL OF VIROLOGY, 1986, 60 (02) :394-399

[9] CHRONIC PROGRESSIVE MYELOPATHY ASSOCIATED WITH ELEVATED ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I AND ADULT T-CELL LEUKEMIA-LIKE CELLS [J].

OSAME, M ;

MATSUMOTO, M ;

USUKU, K ;

IZUMO, S ;

IJICHI, N ;

AMITANI, H ;

TARA, M ;

IGATA, A .

ANNALS OF NEUROLOGY, 1987, 21 (02) :117-122

[10]

OSAME M, 1986, LANCET, V1, P1031