DESIGN, SYNTHESIS, AND ANTITUMOR ACTIVITY-ABSOLUTE CONFIGURATION RELATIONSHIPS OF PODOPHYLLOTOXIN AZA-ANALOGS

被引：56

作者：

TOMIOKA, K

KUBOTA, Y

KOGA, K

机构：

[1] Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo

来源：

TETRAHEDRON | 1993年 / 49卷 / 09期

关键词：

D O I：

10.1016/S0040-4020(01)80545-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active and racemic podophyllotoxin aza-analogues 3 approximately 7 were designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 10 or 16 with 3,4,5-trimethoxybenzaldehyde 11 and were found to show a promising in vitro and in vivo antitumor activity.

引用

页码：1891 / 1900

页数：10

共 25 条

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