MUTATIONS OF KI-RAS ONCOGENE CODON-12 IN BETEL QUID CHEWING-RELATED HUMAN ORAL SQUAMOUS-CELL CARCINOMA IN TAIWAN

被引:63
作者
KUO, MYP
JENG, JH
CHIANG, CP
HAHN, LJ
机构
[1] School of Dentistry, National Taiwan University, Taipei
关键词
BETEL QUID CHEWING; ORAL CANCER; RAS ONCOGENES;
D O I
10.1111/j.1600-0714.1994.tb00259.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
In Taiwan, there are two million people who have a betel quid chewing habit, and approximately 80% of all oral cancer deaths are associated with this habit. To investigate the incidence and types of Ki-rus codon 12 mutations in oral cancer associated with betel quid chewing, we used a sensitive mutation-specific two-stage polymerase chain reaction (PCR) technique to examine human oral squamous cell carcinomas from formalin-fixed, paraffin-embedded tissues. DNA sequence analysis of PCR products revealed that 6 of 33 (18%) tumour specimens contained Ki-ras codon 12 mutations. Four of the tumours contained more than one mutation. Three different base changes were detected, resulting from a substitution of wild type glycine (GGT) to either serine (AGT), aspartic acid (GAT) or cysteine (TAT). These results indicate that Ki-ras oncogene activation may play a role in the oncogenesis of betel quid chewing-related human oral squamous cell carcinomas.
引用
收藏
页码:70 / 74
页数:5
相关论文
共 38 条
  • [1] ALBINO AP, 1989, ONCOGENE, V4, P1363
  • [2] AZUMA M, 1987, CANCER J, V1, P376
  • [3] RAS GENES
    BARBACID, M
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 : 779 - 827
  • [4] PREVALENCE OF RAS GENE-MUTATIONS IN HUMAN COLORECTAL CANCERS
    BOS, JL
    FEARON, ER
    HAMILTON, SR
    VERLAANDEVRIES, M
    VANBOOM, JH
    VANDEREB, AJ
    VOGELSTEIN, B
    [J]. NATURE, 1987, 327 (6120) : 293 - 297
  • [5] BOS JL, 1989, CANCER RES, V49, P4682
  • [6] TUMORIGENIC TRANSFORMATION OF MAMMALIAN-CELLS INDUCED BY A NORMAL HUMAN-GENE HOMOLOGOUS TO THE ONCOGENE OF HARVEY MURINE SARCOMA-VIRUS
    CHANG, EH
    FURTH, ME
    SCOLNICK, EM
    LOWY, DR
    [J]. NATURE, 1982, 297 (5866) : 479 - 483
  • [7] RAS MUTATIONS IN UNITED-KINGDOM EXAMPLES OF ORAL MALIGNANCIES ARE INFREQUENT
    CHANG, SE
    BHATIA, P
    JOHNSON, NW
    MORGAN, PR
    MCCORMICK, F
    YOUNG, B
    HIORNS, L
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1991, 48 (03) : 409 - 412
  • [8] EXPRESSION OF P21RAS IN NORMAL AND MALIGNANT HUMAN-TISSUES - LACK OF ASSOCIATION WITH PROLIFERATION AND MALIGNANCY
    CHESA, PG
    RETTIG, WJ
    MELAMED, MR
    OLD, LJ
    NIMAN, HL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) : 3234 - 3238
  • [9] CLAIR T, 1987, CANCER RES, V47, P5290
  • [10] MECHANISM OF MUTAGENESIS BY O-6-METHYLGUANINE
    EADIE, JS
    CONRAD, M
    TOORCHEN, D
    TOPAL, MD
    [J]. NATURE, 1984, 308 (5955) : 201 - 203