ELECTRICAL-STIMULATION OF THE SCIATIC-NERVE ALTERS NEUROPEPTIDE CONTENT AND LYMPHOCYTE MIGRATION IN THE SUBCUTANEOUS TISSUE OF THE RAT HIND PAW

被引：7

作者：

HERZBERG, U ^{[1
]}

MURTAUGH, MP ^{[1
]}

MULLET, MA ^{[1
]}

BEITZ, AJ ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT VET PATHOBIOL,ST PAUL,MN 55108

来源：

NEUROREPORT | 1995年 / 6卷 / 13期

关键词：

SUBSTANCE P; VASOACTIVE INTESTINAL PEPTIDE; T LYMPHOCYTES; SCIATIC; IMMUNE RESPONSE;

D O I：

10.1097/00001756-199509000-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To study the possible mechanism by which peripheral nerves mediate immune responses in target tissues, electrical stimulation of the sciatic nerve was combined with subcutaneous microdialysis of the hind paw. Following unilateral stimulation of the sciatic nerve, an ipsilateral rise in substance P and a bilateral rise in VIP levels were observed in dialysate samples from experimental us control animals. Electrical stimulation of the sciatic nerve induced a marked hyperemia and swelling of the ipsilateral paw. Quantitative immunocytochemical analysis of paraffin-embedded sections of the hind foot pads demonstrated T lymphocyte migration ipsilateral to the stimulated nerve. These findings suggest that peripheral nerves can directly modulate local immune and inflammatoryresponses.

引用

页码：1773 / 1777

页数：5

共 18 条

[1] LOCAL EDEMA AND GENERAL EXCITATION OF CUTANEOUS SENSORY RECEPTORS PRODUCED BY ELECTRICAL-STIMULATION OF SAPHENOUS NERVE IN RAT [J].