学术探索
学术期刊
新闻热点
数据分析
智能评审

COMPACTIN (ML-236B) AND RELATED-COMPOUNDS AS POTENTIAL CHOLESTEROL-LOWERING AGENTS THAT INHIBIT HMG-COA REDUCTASE

被引：261
作者：
ENDO, A
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 04期
关键词：
D O I：
10.1021/jm00382a001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：401 / 405
页数：5
相关论文
共 45 条
  • [1] DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS-TERREUS
    ALBERSSCHONBERG, G
    JOSHUA, H
    LOPEZ, MB
    HENSENS, OD
    SPRINGER, JP
    CHEN, J
    OSTROVE, S
    HOFFMAN, CH
    ALBERTS, AW
    PATCHETT, AA
    [J]. JOURNAL OF ANTIBIOTICS, 1981, 34 (05) : 507 - 512
  • [2] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT
    ALBERTS, AW
    CHEN, J
    KURON, G
    HUNT, V
    HUFF, J
    HOFFMAN, C
    ROTHROCK, J
    LOPEZ, M
    JOSHUA, H
    HARRIS, E
    PATCHETT, A
    MONAGHAN, R
    CURRIE, S
    STAPLEY, E
    ALBERSSCHONBERG, G
    HENSENS, O
    HIRSHFIELD, J
    HOOGSTEEN, K
    LIESCH, J
    SPRINGER, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07): : 3957 - 3961
  • [3] MEVINOLIN AND COLESTIPOL STIMULATE RECEPTOR-MEDIATED CLEARANCE OF LOW-DENSITY LIPOPROTEIN FROM PLASMA IN FAMILIAL HYPERCHOLESTEROLEMIA HETEROZYGOTES
    BILHEIMER, DW
    GRUNDY, SM
    BROWN, MS
    GOLDSTEIN, JL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13): : 4124 - 4128
  • [4] CRYSTAL AND MOLECULAR-STRUCTURE OF COMPACTIN, A NEW ANTIFUNGAL METABOLITE FROM PENICILLIUM-BREVICOMPACTUM
    BROWN, AG
    SMALE, TC
    KING, TJ
    HASENKAMP, R
    THOMPSON, RH
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (11): : 1165 - 1173
  • [5] REGULATION OF PLASMA-CHOLESTEROL BY LIPOPROTEIN RECEPTORS
    BROWN, MS
    KOVANEN, PT
    GOLDSTEIN, JL
    [J]. SCIENCE, 1981, 212 (4495) : 628 - 635
  • [6] BROWN MS, 1978, J BIOL CHEM, V253, P1121
  • [7] CARSON DD, 1979, P NATL ACAD SCI USA, V76, P5709, DOI 10.1073/pnas.76.11.5709
  • [8] CIEGLER A, 1971, MICROBIAL TOXINS, V5
  • [9] COHEN DC, 1982, J BIOL CHEM, V257, P9429
  • [10] COHEN DC, 1982, J BIOL CHEM, V257, P1106
12345