DIFFERENTIAL DEVELOPMENT OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN THE RAT-BRAIN

被引：80

作者：

TSUTSUMI, K

SAAVEDRA, JM

机构：

[1] Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD

来源：

ENDOCRINOLOGY | 1991年 / 128卷 / 01期

关键词：

D O I：

10.1210/endo-128-1-630

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin II receptors in selected brain areas were characterized into two distinct subtypes by displacement with specific antagonists. The receptor subtypes had different developmental patterns. Type-1 receptors, selectively displaced by the specific angiotensin antagonist DuP-753, were predominant in adult (8-weeks-old) rats. Type-2 receptors were selectively displaced by CGP 42112 A and were expressed remarkably in young (2-weeks-old) rats.

引用

收藏

页码：630 / 632

页数：3

相关论文

共 12 条

[1] EFFECT OF AGE ON SPECIFIC ANGIOTENSIN-II-BINDING SITES IN RAT-BRAIN [J].

BAXTER, CR ;

HORVATH, JS ;

DUGGIN, GG ;

TILLER, DJ .

ENDOCRINOLOGY, 1980, 106 (03) :995-999

[2]

CHIU AT, 1989, J PHARMACOL EXP THER, V250, P867

[3] IDENTIFICATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES [J].

CHIU, AT ;

HERBLIN, WF ;

MCCALL, DE ;

ARDECKY, RJ ;

CARINI, DJ ;

DUNCIA, JV ;

PEASE, LJ ;

WONG, PC ;

WEXLER, RR ;

JOHNSON, AL ;

TIMMERMANS, PBMWM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) :196-203

[4] ONTOGENY OF RENIN-INDUCED SALT APPETITE IN THE RAT PUP [J].

LESHEM, M ;

EPSTEIN, AN .

DEVELOPMENTAL PSYCHOBIOLOGY, 1989, 22 (05) :437-445

[5] AUTORADIOGRAPHIC LOCALIZATION OF ANGIOTENSIN-II RECEPTORS IN RAT-BRAIN [J].

MENDELSOHN, FAO ;

QUIRION, R ;

SAAVEDRA, JM ;

AGUILERA, G ;

CATT, KJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1575-1579

[6] A NEW DENSITOMETRIC PROCEDURE TO MEASURE PROTEIN-LEVELS IN TISSUE-SLICES USED IN QUANTITATIVE AUTORADIOGRAPHY [J].

MILLER, JA ;

CURELLA, P ;

ZAHNISER, NR .

BRAIN RESEARCH, 1988, 447 (01) :60-66

[7] CALIBRATION OF I-125 POLYMER STANDARDS WITH I-125 BRAIN PASTE STANDARDS FOR USE IN QUANTITATIVE RECEPTOR AUTORADIOGRAPHY [J].

NAZARALI, AJ ;

GUTKIND, JS ;

SAAVEDRA, JM .

JOURNAL OF NEUROSCIENCE METHODS, 1989, 30 (03) :247-253

[8] FUNCTIONS OF ANGIOTENSIN IN THE CENTRAL-NERVOUS-SYSTEM [J].

PHILLIPS, MI .

ANNUAL REVIEW OF PHYSIOLOGY, 1987, 49 :413-435

[9] BINDING OF ANGIOTENSIN AND ATRIAL-NATRIURETIC-PEPTIDE IN BRAIN OF HYPERTENSIVE RATS [J].

SAAVEDRA, JM ;

CORREA, FMA ;

PLUNKETT, LM ;

ISRAEL, A ;

KURIHARA, M ;

SHIGEMATSU, K .

NATURE, 1986, 320 (6064) :758-760

[10]

TSUTSUMI K, IN PRESS J NEUROCHEM