IL-5 PREDOMINANT IN BRONCHOALVEOLAR LAVAGE FLUID AND PERIPHERAL-BLOOD IN A PATIENT WITH ACUTE EOSINOPHILIC PNEUMONIA

被引：18

作者：

YAMAGUCHI, S

OKUBO, Y

HOSSAIN, M

FUJIMOTO, K

HONDA, T

KUBO, K

SEKIGUCHI, M

TAKATSU, K

机构：

[1] The First Department of Internal Medicine, Shinshu University, School of Medicine, Matsumoto

[2] The Department of Immunology, Institute of Medical Science, University of Tokyo, Tokyo

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 01期

关键词：

EOSINOPHILS; CYTOKINE; BRONCHOALVEOLAR LAVAGE; RESPIRATORY DISTRESS;

D O I：

10.2169/internalmedicine.34.65

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe an acute eosinophilic pneumonia (AEP) patient with bronchoalveolar lavage fluid (BALF). Eosinophil cell number (47%), content of interleukin (IL)-5 (8.22x10(2) pg/ml) and eosinophil cationic protein (9.25 mug/ml) were high in BALF. No eosinophilia was seen in peripheral blood on admission; however, content of IL-5 was 9.47x10(2) pg/ml. After methylprednisolone pulse therapy, he improved rapidly with a reduction in eosinophil cell number (7%) and the content of IL-5 (<100 pg/ml) in BALF. However, a high content of IL-5 (6.9x10(2) pg/ml) and transient eosinophilia (17.5%) were seen in peripheral blood. It is important to distinguish between AEP and infectious pneumonia, because of the differing treatments. If the diagnosis of AEP is doubtful, BALF should be performed early.

引用

页码：65 / 68

页数：4

共 13 条

[1]

Liebow A.A., Carrington C.B., The eosinophilic pneumonias, Medicine, 48, (1969)

[2]

Pinkston P., Vijayan V.K., Nutman T.B., Acute tropical pulmonary eosinophilia: characterization of the lower respiratory tract inflammation and its response to therapy, J Clin Invest, 80, (1987)

[3]

Cooper J.A., White D.A., Matthay R.A., Drug induced pulmonary disease, Am Rev Respir Dis, 133, (1986)

[4]

De Nonchy J.G., Kauffman H.F., Venge P., Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions, Am Rev Respir Dis, 131, (1985)

[5]

Badesch D.B., King T.E., Schwarz M.I., Acute eosinophilic pneumonia: a hypersensitivity pneumonia?, Am Rev Respir Dis, 139, (1989)

[6]

Allen J.N., Pacht E.R., Gadek J.E., Davis W.B., Acute eosinophilic pneumonia as a reversible cause of noninfectious respiratory failure, N Engl J Med, 321, (1989)

[7]

Kita H., Ohnishi T., Okubo Y., Weiler D., Abrams J., Gleich G.J., Granulocyte/macrophage colony-stimulating factor and interleukin-3 release from human peripheral blood eosinophils and neutrophils, J Exp Med, 174, (1991)

[8]

Corrigan C.J., Haczku A., Gemou-engesaeth V., Doi S., Kikuchi Y., Takatsu K., Durham S.R., Kay A.B., CD4T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5, Am Rev Respir Dis, 147, (1993)

[9]

Greenburg M., Schiffman R.L., Gefa D.G., Acute eosinophilic pneumonia, N Engl J Med, 322, (1990)

[10]

Acute eosinophilic pneumonia, Lancet, 335, (1990)

← 1 2 →