THE 210-KD NUCLEAR-ENVELOPE POLYPEPTIDE RECOGNIZED BY HUMAN AUTOANTIBODIES IN PRIMARY BILIARY-CIRRHOSIS IS THE MAJOR GLYCOPROTEIN OF THE NUCLEAR-PORE

被引：109

作者：

COURVALIN, JC

LASSOUED, K

BARTNIK, E

BLOBEL, G

WOZNIAK, RW

机构：

[1] CNRS, CTR GENET MOLEC, F-91190 GIF SUR YVETTE, FRANCE

[2] INSERM, U108, IMMUNOCHIM & IMMUNOPATHOL LAB, F-75005 PARIS, FRANCE

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1990年 / 86卷 / 01期

关键词：

autoantibodies; glycoprotein; 210; nuclear pore; primary biliary cirrhosis;

D O I：

10.1172/JCI114696

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of ~ 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.

引用

收藏

页码：279 / 285

页数：7

相关论文

共 43 条

[1] IMMUNOLOGY OF PRIMARY BILIARY-CIRRHOSIS [J].

BERG, PA ;

KLEIN, R .

BAILLIERES CLINICAL GASTROENTEROLOGY, 1987, 1 (03) :674-706

[2] ANTICENTROMERE ANTIBODY IN PRIMARY BILIARY-CIRRHOSIS [J].

BERNSTEIN, RM ;

CALLENDER, ME ;

NEUBERGER, JM ;

HUGHES, GRV ;

WILLIAMS, R .

ANNALS OF THE RHEUMATIC DISEASES, 1982, 41 (06) :612-614

[3]

BERNSTEIN RM, 1984, CLIN EXP IMMUNOL, V55, P553

[4]

BERRIOS M, 1983, J BIOL CHEM, V258, P3384

[5]

BERRIOS M, 1983, J BIOL CHEM, V258, P4548

[6] NUCLEI FROM RAT LIVER - ISOLATION METHOD THAT COMBINES PURITY WITH HIGH YIELD [J].

BLOBEL, G ;

POTTER, VR .

SCIENCE, 1966, 154 (3757) :1662-&

[7] FILM DETECTION METHOD FOR TRITIUM-LABELED PROTEINS AND NUCLEIC-ACIDS IN POLYACRYLAMIDE GELS [J].

BONNER, WM ;

LASKEY, RA .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1974, 46 (01) :83-88

[8] ISOLATION AND ANALYSIS OF CDNA CLONES EXPRESSING HUMAN LUPUS LA ANTIGEN [J].

CHAMBERS, JC ;

KEENE, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (07) :2115-2119

[9]

CHRISTENSEN E, 1980, GASTROENTEROLOGY, V78, P236

[10] PRIMARY STRUCTURE OF THE HUMAN M2 MITOCHONDRIAL AUTO-ANTIGEN OF PRIMARY BILIARY-CIRRHOSIS - DIHYDROLIPOAMIDE ACETYLTRANSFERASE [J].

COPPEL, RL ;

MCNEILAGE, LJ ;

SURH, CD ;

VANDEWATER, J ;

SPITHILL, TW ;

WHITTINGHAM, S ;

GERSHWIN, ME .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7317-7321

← 1 2 3 4 5 →